MetaMax continues to develop platform technology based on internalized peptide sequences

A Russian private biotechnology company Metamax, Ltd, financed by Maxwell Biotech Venture Fund, set up with the participation of RVC, has successfully completed the preclinical studies of the leading drug for treatment of colorectal cancer MM-D37K which is a special case of the technological platform based on internalized peptide sequences. 
The Chief Scientific Adviser of Metamax Prof. Vladimir Bozhenko has presented the results of preclinical trials of the drug MM-D37K at the 38th Congress of the Federation of European Biochemical Societies (FEBS), held in St. Petersburg in July, 2013. This event is one of the most representative platforms for the demonstration of the latest achievements in the field of biochemical science. Annually more than 3,000 delegates from all over the world take part in this Congress. 
Preclinical studies have shown the agent’s promising therapeutic activity against various cancer models (in vitro and in vivo) and presented the evidence of the additive and cumulative effect of MM-D37K and standard chemotherapeutic agents (in vitro). Safety studies have also been successfully completed. All the results of the preclinical work will be published in the collection of abstracts of the ASCO Annual Meeting 2013, whose annual Congresses on issues of oncology are the most famous in the world and the number of participants of each meeting is more than 30000 specialists. 
The company is planning to file documents to the Ministry of Health of the Russian Federation for approval of Phase I/IIa clinical trial in oncological subjects with tumors of the gastrointestinal cancer until the end of the august.
It ought to be remarked that the development of cycline-dependent kinase inhibitors 4/6 is one of the most perspective line (trend direction) in searching drugs in oncology.  However, in contrast to products developed by large pharmaceutical companies that are low-molecular inhibitors and interact with ATP-binding domains of cycline-dependent kinase, the MetaMax’s product inhibits cycline-dependent kinases by the protein-protein interaction with the functional peptide sequence of the protein p16 which modulates the natural activation of tumor cells apoptosis. The biology of the product MM-D37K affords to avoid drug resistance, specific to low molecular drugs.
Parallel to the development of the leading drug MM-37K MetaMax has successfully conducted the searching and screening of new cytotoxic sequences, based on the sequence of protein inhibitor of the cycline-dependent kinase inhibitors 4/6. As a result the most perspective peptide with the highest cytotoxic activity against several tumor cell lines has been chosen. This peptide will continue preclinical studies of efficacy and safety for the expansion of the product portfolio of the company MetaMax. Series of preclinical studies of efficacy in particular are planned on models of melanoma (skin cancer) and glioblastoma (brain cancer) which are often associated with the loss of the p16 protein functions responsible for the apoptosis activation through the inhibition of the cycline-dependent kinase 4/6.
About Maxwell Biotech Group
Maxwell Biotech Group (MBG) is a development partner and financial resource for innovative biotechnology companies. MBG provides investment capital and access to an established infrastructure for conducting high-quality clinical trials in Russia, and helps enable the rapid and cost-effective achievement of clinical objectives. Our unique business model can add value to our partners’ pipelines and provide a commercialization path to one of the most lucrative emerging markets. MBG relies on an experienced international team of managers and financial and industry experts. The Group includes 10 innovative biotechnological projects, developing in the portfolio companies: OncoMax, Photonics, MetaMax, Infectex, NeuroMax, CardioNova, Hepatera, Osteros Biomedica, Eleventa.   All the group’s companies are the residents of the Biomed Cluster at Skolkovo Innovation Center and 5 of them are members of the Technology Platform “The Medicine of the Future”. 
For further information, please contact
Anna Sitnikova, Chief public relations Expert “Maxwell Biotech Group”
Tel. (495) 411-6992
About MetaMax
MetaMax is a private biotech company founded with the goal of developing and marketing innovative biopharmaceutical drugs that target most prevalent and dangerous systemic diseases. MetaMax is Skolkovo resident and takes part in Technology Platform “Medicine of the Future”. MetaMax’s first product – MM-D37K – is an intravenously administered chimeric peptide to treat colorectal and other gastrointestinal cancers. Preclinical studies showed the agent’s promising therapeutic activity against various cancer models (in vitro and in vivo) and presented evidence of the additive and cumulative effect of MM-D37K and standard chemotherapeutic agents (in vitro). 
About Russian Venture Company
RVC is a government fund of funds and a development institute of the Russian Federation, one of Russia's key tools in building its own national innovation system.
RVC was established by Russian Government on June 7, 2006 (Order No. 838-r). Its mission is to encourage Russia’s own VC industry and boost capital of VC funds. RVC’s role is that of a government fund of venture capital funds channeling public incentives to venture capital and financial support to the hi-tech sector, and of a Russian VC industry development institution.
RVC’s authorized capital — RUB 30 011 320 700 (about US$ 983.2 mln) — is 100% owned by the Federal Agency for State Property Management (Rosimuschestvo). RVC has backed 12 funds to a total capitalization of RUB 26.1 bln, its share amounting to RUB 16 bln. As on January 2013, RVC backed funds run a portfolio of 139 companies, invested capital totaling more than RUB 12.1 bln. 
For further information, please contact
Natalia Samokhvalova, Chief public relations Expert RVC
Tel. (495) 411-6992



Anna Sitnikova,
Chief public relations Expert Maxwell Biotech Group;
Tel.: +7 (495) 411-6992